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1 Bottle

30 Day Supply

YOU SAVE $180!

$249 $69

+ Shipping

3 Bottles

90 Day Supply

YOU SAVE $570!

$747 $177

+ Shipping

6 Bottles

180 Day Supply

YOU SAVE $1,200!

$1,494 $294

+ Shipping

*If you see order buttons above, then we have limited bottles available for order. Act fast to avoid disappointment.

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Scientific References

1.Marino, G., Pietrocola, F., Madeo, F., & Kroemer, G. (2014). Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers. Autophagy, 10(11), 1879-1882.
2.Donald K. Ingrama,∗, George S. Roth. Calorie restriction mimetics: Can you have your cake and eat it, too? Ageing Research Reviews, (2015) 20, 46-62
3. Tomas‐Hernández, S., Blanco, J., Rojas, C., Roca‐Martínez, J., Ojeda‐Montes, M. J., Beltrán‐Debón, R., ... & Mulero, M. (2018). Resveratrol potently counteracts quercetin starvation‐induced autophagy and sensitizes HepG2 cancer cells to apoptosis. Molecular Nutrition & Food Research, 62(5), 1700610
4. Assylzhan Yessenkyzy 1 , Timur Saliev 1,* , Marina Zhanaliyeva 2 , Abdul-Razak Masoud 3 , Bauyrzhan Umbayev 4 , Shynggys Sergazy 4 , Elena Krivykh 5 , Alexander Gulyayev 4 and Talgat Nurgozhin, Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research. Nutrients 2020, 12, 1344
5. Frank Madeo, Didac Carmona-Gutierrez, Sebastian J. Hofer, Guido Kroemer, Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential, Cell Metabolism, Volume 29, Issue 3, 2019, Pages 592-610
Choi, C., Song, H.-D., Son, Y., Cho, Y. K., Ahn, S.-Y., Jung, Y.-S., Yoon, Y. C., Kwon, S. W., & Lee, Y.-H. (2020). Epigallocatechin-3-Gallate Reduces Visceral Adiposity Partly through the Regulation of Beclin1-Dependent Autophagy in White Adipose Tissues. Nutrients, 12(10), 3072.
Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019). Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential. Cell metabolism, 29(3), 592-610.
8. Zhenyu Zhong, Elsa Sanchez-Lopez, Michael Karin, Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment, Cell, Volume 166, Issue 2, 2016, Pages 288-298
9. Van Cauwenberghe, C., Vandendriessche, C., Libert, C., & Vandenbroucke, R. E. (2016). Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease. Mammalian genome, 27(7-8), 300-319
10. Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018). Autophagy in cardiovascular aging. Circulation research, 123(7), 803-824
11. Chiba, T., Tsuchiya, T., Komatsu, T., Mori, R., Hayashi, H., & Shimokawa, I. (2010). Development of calorie restriction mimetics as therapeutics for obesity, diabetes, inflammatory and neurodegenerative diseases. Current Genomics, 11(8), 562-567.
12. Bachar-Wikstrom, E., Wikstrom, J. D., Ariav, Y., Tirosh, B., Kaiser, N., Cerasi, E., & Leibowitz, G. (2013). Stimulation of autophagy improves endoplasmic reticulum stress–induced diabetes. Diabetes, 62(4), 1227-1237.
13. Federico Pietrocola, Jonathan Pol, Erika Vacchelli, Shuan Rao, David P. Enot, Elisa E. Baracco, Sarah Levesque, Francesca Castoldi, Nicolas Jacquelot, Takahiro Yamazaki, Laura Senovilla, Guillermo Marino, Fernando Aranda, Sylvère Durand, Valentina Sica, Alexis Chery, Sylvie Lachkar, Verena Sigl, Norma Bloy, Aitziber Buque, Simonetta Falzoni, Bernhard Ryffel, Lionel Apetoh, Francesco Di Virgilio, Frank Madeo, Maria Chiara Maiuri, Laurence Zitvogel, Beth Levine, Josef M. Penninger, Guido Kroemer, Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance, Cancer Cell, Volume 30, Issue 1, 2016, Pages 147-160,
14. Pietrocola, F., Pol, J., Vacchelli, E., Baracco, E. E., Levesque, S., Castoldi, F., ... & Kroemer, G. (2016). Autophagy induction for the treatment of cancer. Autophagy, 12(10), 1962-1964.
15. Enrique Gabandé-Rodríguez 1,2,3,* , Manuel M. Gómez de las Heras 1,2,3 and María Mittelbrunn. Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria (2020) Cells, 9, 82
16. Fernández, Á. F., Bárcena, C., Martínez-García, G. G., Tamargo-Gómez, I., Suárez, M. F., Pietrocola, F., ... & López-Otín, C. (2017). Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens. Cell death & disease, 8(8), e2970-e2970
17. Meng, Q., & Cai, D. (2011). Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway. Journal of Biological Chemistry, 286(37), 32324-32332
18. Choi, C., Song, H.-D., Son, Y., Cho, Y. K., Ahn, S.-Y., Jung, Y.-S., Yoon, Y. C., Kwon, S. W., & Lee, Y.-H. (2020). Epigallocatechin-3-Gallate Reduces Visceral Adiposity Partly through the Regulation of Beclin1-Dependent Autophagy in White Adipose Tissues. Nutrients, 12(10), 3072
† Statements on this website have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using our products.
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